[Retinal angiomatous proliferation with associated pigment epithelium detachment: anti-VEGF therapy].

摘要: Background Vascularized pigment epithelial detachment (PED) in retinal angiomatous proliferation (RAP) represents a special morphological form of exudative age-related macular degeneration (ARMD) the natural course and frequency complications, such as tears epithelium. In this study results inhibition vascular endothelial growth factor (VEGF) for ARMD with associated PED RAP were examined. Materials methods Functional data retrospectively collected 61 consecutive eyes stages 2 3 over an average observation period 108 weeks. Patients treated bevacizumab (n=15), ranibizumab (n=29) pegabtanib (n=17) according to recommendations German Society Ophthalmology (DOG) Retina (RG). After initial treatment cycle injections every 4 weeks (6 pegabtanib), best corrected visual acuity (BCVA), fluorescence angiography (FAG), indocyanine green (ICG-A) optical coherence tomography (OCT) evaluated 12 Results The mean was 0.8 logMAR before therapy 0.77 after so that difference original -0.03 0.00 48 central thickness measured by OCT decreased on 81.2 µm first -68.4 1 year. maximum depth could be reduced unit year 1.55 units. Better functional obtained avastin compared (p=0.03). An RIP occurred 9.8% patients (n=6) 16 Conclusions can improved early months using strategy presently recommended Germany. However, later there significant worsening results. Modification respect close surveillance possibly stage repeat would seem advisable.