6-(substituted)methylenepenicillanic and 6-(substituted)hydroxymethylpenicillanic acids and derivatives thereof
作者： Yuhpyng Liang Chen
DOI:
关键词: Chemistry 、 Carboxylate 、 Aryl 、 Stereochemistry 、 Residue (chemistry)
摘要: Beta-lactamase inhibiting compounds of the formula ##STR1## or a pharmaceutically acceptable acid addition carboxylate salt thereof; where n is zero, 1 2; X 3 H Br, R H, residue certain carboxy-protecting groups an ester group readily hydrolyzable in vivo; one 12 and 13 other vinyl, aryl, alkylthio, alkylsulfonyl heterocyclyl, aminomethyl, thiocarboxamido amidino groups; 2 as disclosed for , Cl CH OH, 18 acyl intermediates useful their production, methods preparation use, pharmaceutical compositions containing them.
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