The Relationship Between the Insulin Receptor Substrates and Metabolic Disease

摘要: Although the regulation of plasma glucose is a dominant response associated with insulin action, homeostasis depends on integration signals in many tissues and cells—hepatocytes, muscle, adipose, hypothalamic neurons, pancreatic β-cells, others (1, 2, 3, 4, 5, 6, 7). Understanding how action coordinated modulated these by heterologous signaling cascades challenging scientific question clinical importance.