Circulating opioids: Possible physiological roles in central nervous function

摘要: Evidence is reviewed regarding the release of endorphins by such diverse conditions as stress, long distance running, acupuncture, sexual activity, suggestion and ritualistic dancing ceremonies. Additional evidence cited possible physiological roles in antinociception, socialization, euphoria, some mental disorders, drive states vegetative functions. The concentration this latter type on during which seem to be exerting effects a number different systems together (for example, euphoria almost always accompanied analgesia), possibility suggested that activation functions may due global opiate receptors throughout CNS. A basis for arises from results laboratory indicating presence blood-borne opioid hormone, secreted pituitary or an endocrine gland under control, capable passing blood into This diffuse endorphinergic system, complementary well-established neuronal CNS, thus derives its property action means hormone reaches target sites, i.e., through brain barrier. Thus, while each specific endorphin-mediated function can activated respective neural pathway, it proposed hormonal mechanism produce response provoked more generalized response, including behavioural changes, most appropriate.