Impact of obesity on renal transplant outcomes.

作者: KIRSTEN A ARMSTRONG , SCOTT B CAMPBELL , CARMEL M HAWLEY , DAVID W JOHNSON , NICOLE M ISBEL

DOI: 10.1111/J.1440-1797.2005.00406.X

关键词: MedicineGlomerulopathyDiabetes mellitusTransplantationImmunosuppressionIntensive care medicineBody mass indexKidney transplantationInsulin resistanceObesity

摘要: Obesity is a frequent and important consideration to be taken into account when assessing patient suitability for renal transplantation. In addition, posttransplant obesity continues represent significant challenge health care professionals caring transplant recipients. Despite the vast amount of evidence that exists on effect pretransplant outcomes, there are still conflicting views regarding whether obese recipients have worse outcome, in terms short- long-term graft survival survival, compared with their non-obese counterparts. It well established any association reduced mediated part by its clustering traditional cardiovascular risk factors such as hypertension, dyslipidaemia, insulin resistance diabetes mellitus, but what not understood mediates failure. Whether it higher incidence comorbidities jeopardising or specific obesity, hyperfiltration glomerulopathy, might implicated, currently remains unknown. can concluded, however, pre- should targeted aggressively more well-established order optimize outcomes.

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