Prognostic Value of MiR-21: An Updated Meta-Analysis in Head and Neck Squamous Cell Carcinoma (HNSCC).
作者： Irimie-Aghiorghiesei , Pop-Bica , Pintea , Braicu , Cojocneanu
DOI: 10.3390/JCM8122041
关键词: Oncology 、 Carcinogenesis 、 Meta-analysis 、 Survival rate 、 Head and neck cancer 、 Head and neck squamous-cell carcinoma 、 Internal medicine 、 Medicine 、 Downregulation and upregulation 、 Radiation therapy 、 Chemotherapy
摘要: Head and neck squamous cell carcinoma (HNSCC) is a group of malignancies with serious impact on patient quality life due to reduced rate response chemotherapy or radiation therapy. MiR-21 has been identified as one the most common proto-oncogenes. It hypothesized that upregulated miR-21 could serve potential biomarker for human cancer diagnosis. Considering target genes in HNSCC, this transcript an important player several cellular processes control carcinogenesis. The abnormal expression pathologies assessed publications, but given heterogeneity published results, meta-analysis proper bioinformatics analysis databases are needed correctly establish prognostic molecule. present comprises survival data HNSCC patients, reported HR 95% CI, association levels miR-21. Our investigation revealed be used successfully confirming its oncogenic potential. Specifically, upregulation these patients predicts worse outcome terms rate.
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Victor Ambros, The functions of animal microRNAs Nature. ,vol. 431, pp. 350- 355 ,(2004) , 10.1038/NATURE02871
Cornelia Braicu, Cristina Catana, George Calin, Ioana Berindan-Neagoe, NCRNA combined therapy as future treatment option for cancer Current Pharmaceutical Design. ,vol. 20, pp. 6565- 6574 ,(2014) , 10.2174/1381612820666140826153529
Shyh-An Yeh, Radiotherapy for head and neck cancer. Seminars in Plastic Surgery. ,vol. 24, pp. 127- 136 ,(2010) , 10.1055/S-0030-1255330
ZHIFENG SUN, SUPING LI, ANDREAS M. KAUFMANN, ANDREAS E. ALBERS, miR-21 increases the programmed cell death 4 gene-regulated cell proliferation in head and neck squamous carcinoma cell lines Oncology Reports. ,vol. 32, pp. 2283- 2289 ,(2014) , 10.3892/OR.2014.3456
Roxana S Redis, Ioana Berindan-Neagoe, Victor I Pop, George A. Calin, Non‐coding RNAs as theranostics in human cancers Journal of Cellular Biochemistry. ,vol. 113, pp. 1451- 1459 ,(2011) , 10.1002/JCB.24038
Geoffrey Childs, Melissa Fazzari, Gloria Kung, Nicole Kawachi, Margaret Brandwein-Gensler, Michael McLemore, Quan Chen, Robert D. Burk, Richard V. Smith, Michael B. Prystowsky, Thomas J. Belbin, Nicolas F. Schlecht, Low-Level Expression of MicroRNAs let-7d and miR-205 Are Prognostic Markers of Head and Neck Squamous Cell Carcinoma The American Journal of Pathology. ,vol. 174, pp. 736- 745 ,(2009) , 10.2353/AJPATH.2009.080731
Yang Wang, Xujie Gao, Feng Wei, Xinwei Zhang, Jinpu Yu, Hua Zhao, Qian Sun, Fan Yan, Cihui Yan, Hui Li, Xiubao Ren, Diagnostic and prognostic value of circulating miR-21 for cancer: A systematic review and meta-analysis Gene. ,vol. 533, pp. 389- 397 ,(2014) , 10.1016/J.GENE.2013.09.038
Nora Hedbäck, David H. Jensen, Lena Specht, Anne-Marie K. Fiehn, Marianne H. Therkildsen, Lennart Friis-Hansen, Erik Dabelsteen, Christian von Buchwald, MiR-21 Expression in the Tumor Stroma of Oral Squamous Cell Carcinoma: An Independent Biomarker of Disease Free Survival PLoS ONE. ,vol. 9, pp. e95193- ,(2014) , 10.1371/JOURNAL.PONE.0095193
Wei Wang, Piao Songlin, Yao Sun, Bin Zhang, Wang Jinhui, miR-21 inhibitor sensitizes human OSCC cells to cisplatin Molecular Biology Reports. ,vol. 39, pp. 5481- 5485 ,(2012) , 10.1007/S11033-011-1350-9
T. Rampias, C. Sasaki, P. Weinberger, A. Psyrri, E6 and E7 Gene Silencing and Transformed Phenotype of Human Papillomavirus 16–Positive Oropharyngeal Cancer Cells Journal of the National Cancer Institute. ,vol. 101, pp. 412- 423 ,(2009) , 10.1093/JNCI/DJP017