HDAC4 Knockdown Induces Preeclampsia Cell Autophagy and Apoptosis by miR-29b.

摘要: Preeclampsia (PE) is one of the main causes maternal death and perinatal morbidity mortality. Considering that histone deacetylase 4 (HDAC4) activity could relate to trophoblast cell motility be antagonized by miR-29b, aim present study was investigate ability HDAC4 regulate placental cells miR-29b. We assessed cytological changes PE patients, expression cellular localization LC3 histological analysis, immunohistochemistry, western blot assay, immunofluorescence staining assay. observed effect hypoxia on HDAC4, correction HDAC4/miR-29b, effects HDAC4/miR-29b HTR8 dual-luciferase, quantitative real-time PCR, flow cytometry Here, we first found lowly expressed in tissues, while highly expressed. In addition, inhibited cells. Furthermore, our data showed highlighted miR-29b specifically targeted both molecules were involved a functional loop. Altogether, findings demonstrated silencing trigger autophagy apoptosis directly PE.