Transcriptional Regulation of Enhancers Active in Protodomains of the Developing Cerebral Cortex
作者： Kartik Pattabiraman , Olga Golonzhka , Susan Lindtner , Alex S. Nord , Leila Taher
DOI: 10.1016/J.NEURON.2014.04.014
关键词: PAX6 、 Genetics 、 Transcriptional regulation 、 Enhancer 、 Transgene 、 Fate mapping 、 Cell biology 、 Regulation of gene expression 、 Cerebral cortex 、 Biology 、 Transcription factor
摘要: Elucidating the genetic control of cerebral cortical (pallial) development is essential for understanding function, evolution, and disorders brain. Transcription factors (TFs) that embryonically regulate pallial regionalization are expressed in gradients, raising question how discrete domains generated. We provide evidence small enhancer elements active protodomains integrate broad transcriptional information. CreER(T2) GFP expression from 14 different stable transgenic mice allowed us to define a comprehensive regional fate map pallium. explored mechanisms activity enhancers using informatics, vivo occupancy by TFs patterning (CoupTFI, Pax6, Pbx1), analysis Pax6 mutants. Overall, results insights into broadly drive gene distinct regions.
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Michio Yoshida, Stavroula Assimacopoulos, Kevin R Jones, Elizabeth A Grove, Massive loss of Cajal-Retzius cells does not disrupt neocortical layer order Development. ,vol. 133, pp. 537- 545 ,(2006) , 10.1242/DEV.02209
J. Jeong, X. Li, R. J. McEvilly, M. G. Rosenfeld, T. Lufkin, J. L. R. Rubenstein, Dlx genes pattern mammalian jaw primordium by regulating both lower jaw-specific and upper jaw-specific genetic programs. Development. ,vol. 135, pp. 2905- 2916 ,(2008) , 10.1242/DEV.019778
V. S. Mangale, K. E. Hirokawa, P. R. V. Satyaki, N. Gokulchandran, S. Chikbire, L. Subramanian, A. S. Shetty, B. Martynoga, J. Paul, M. V. Mai, Y. Li, L. A. Flanagan, S. Tole, E. S. Monuki, Lhx2 selector activity specifies cortical identity and suppresses hippocampal organizer fate Science. ,vol. 319, pp. 304- 309 ,(2008) , 10.1126/SCIENCE.1151695
Linda Madisen, Theresa A Zwingman, Susan M Sunkin, Seung Wook Oh, Hatim A Zariwala, Hong Gu, Lydia L Ng, Richard D Palmiter, Michael J Hawrylycz, Allan R Jones, Ed S Lein, Hongkui Zeng, A robust and high-throughput Cre reporting and characterization system for the whole mouse brain Nature Neuroscience. ,vol. 13, pp. 133- 140 ,(2010) , 10.1038/NN.2467
Maria Armentano, Shen-Ju Chou, Giulio Srubek Tomassy, Axel Leingärtner, Dennis D M O'Leary, Michèle Studer, COUP-TFI regulates the balance of cortical patterning between frontal/motor and sensory areas. Nature Neuroscience. ,vol. 10, pp. 1277- 1286 ,(2007) , 10.1038/NN1958
J L Rubenstein, K Yun, S Potter, Gsh2 and Pax6 play complementary roles in dorsoventral patterning of the mammalian telencephalon Development. ,vol. 128, pp. 193- 205 ,(2001) , 10.1242/DEV.128.2.193
Dennis D.M. O'Leary, Shen-Ju Chou, Setsuko Sahara, Area patterning of the mammalian cortex Neuron. ,vol. 56, pp. 252- 269 ,(2007) , 10.1016/J.NEURON.2007.10.010
Jean M Hébert, Susan K McConnell, Targeting of cre to the Foxg1 (BF-1) locus mediates loxP recombination in the telencephalon and other developing head structures. Developmental Biology. ,vol. 222, pp. 296- 306 ,(2000) , 10.1006/DBIO.2000.9732
V. V. Chizhikov, A. G. Lindgren, Y. Mishima, R. W. Roberts, K. A. Aldinger, G. R. Miesegaes, D. S. Currle, E. S. Monuki, K. J. Millen, Lmx1a regulates fates and location of cells originating from the cerebellar rhombic lip and telencephalic cortical hem Proceedings of the National Academy of Sciences of the United States of America. ,vol. 107, pp. 10725- 10730 ,(2010) , 10.1073/PNAS.0910786107
Ugo Borello, Mayur Madhavan, Ilya Vilinsky, Andrea Faedo, Alessandra Pierani, John Rubenstein, Kenneth Campbell, Sp8 and COUP-TF1 Reciprocally Regulate Patterning and Fgf Signaling in Cortical Progenitors Cerebral Cortex. ,vol. 24, pp. 1409- 1421 ,(2014) , 10.1093/CERCOR/BHS412