Aromatic Metamorphosis of Thiophenes by Means of Desulfurative Dilithiation.
作者： Atsushi Kaga , Hirokazu Iida , Shun Tsuchiya , Hayate Saito , Koji Nakano
关键词: Lithium metal 、 Double bond 、 Thiophene 、 Heteroatom 、 Lithium 、 Combinatorial chemistry 、 Chemistry 、 Benzene 、 Sulfur 、 Electrophile
摘要: A new mode of aromatic metamorphosis has been developed, which allows thiophenes and their benzo-fused derivatives to be converted a variety exotic heteroles. This transformation involves 1) the efficient generation key 1,4-dianions by means desulfurative dilithiation with lithium powder 2) the subsequent trapping the dianions heteroatom electrophiles in one-pot manner. Via dilithiation, sulfur atoms are replaced also carbon-carbon double bond or 1,2-phenylene for construction benzene rings.
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