Covalent Modification of Silicon Nitride Nanopore by Amphoteric Polylysine for Short DNA Detection.
作者： Bohua Yin , Wanyi Xie , Liyuan Liang , Yunsheng Deng , Shixuan He
关键词: Electrolyte 、 Chemical bond 、 Silicon nitride 、 Covalent bond 、 Analytical chemistry 、 Nanopore 、 Conductance 、 Chemical modification 、 Charge density 、 Chemistry 、 Chemical engineering
摘要: In this work, we demonstrate a chemical modification approach, by means of covalent-bonding amphoteric poly-l-lysine (PLL) on the interior nanopore surface, which could intensively protect pore from etching when exposed in electrolyte under various pH conditions (from 4 to 12). Nanopore was generated via simple current dielectric breakdown methodology, covalent performed three steps, and functional fully characterized terms structure, hydrophilicity, surface morphology. I–V curves were recorded broad range stimuli evaluate stability bonding layer; plotted demonstrated that with layer has good tolerance showed apparent reversibility. addition, have also measured conductance modified varied KCl concentration 0.1 mM 1 M) at different (pHs 5, 7, 9, 11). The results suggested charge density do...
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