Leukemia risk in children exposed to benzene and PM10 from vehicular traffic: a case–control study in an Italian population

摘要: Benzene, a recognized occupational leukemogen in adults, has been hypothesized to also increase the risk of childhood leukemia. We carried out population-based case-control study northern Italy community involving 83 cases with acute leukemia diagnosed years 1998-2009 and 332 matched controls. assessed residential exposure benzene particulate matter ≤10 μm (PM10) from motorized traffic using geocoded residences detailed emission dispersion modeling. Exposure benzene, lesser extent PM10, appeared be independently associated an excess risk. When we stratified population by age subtype, relative was higher among children aged less than 5 years, despite small numbers this relation considerably stronger for myeloid lymphoblastic Overall, these findings suggest that low levels released may leukemia, possible independent effect although unmeasured confounding due other pollutants cannot ruled out.