Stereotactic Radiotherapy: A Technique for Dose Optimization and Escalation for Intracranial Tumors

摘要: Stereotactic radiosurgery offers the ability to treat relatively small volume intracranial lesions with single fraction, high dose radiotherapy while sparing surrounding tissue due rapid fall off of outside treatment volume. Conventional takes advantage effects fractionation, but includes large amounts normal brain in tolerance which is dose-limiting. For some it may not be optimal fractions tumor location or size. fractionated optimum all cases necessary inclusion structures. Through development relocatable head frames, precision stereotactic techniques and biologic advantages fractionation combined (SRT). We report on 68 patients using a dedicated linear accelerator deliver SRT between June 1992 1993. was used either order optimize distribution spare tissues excellent prognosis increase keeping doses below levels poorer (dose escalation). Histologies treated included meningioma, low grade astrocytoma, pituitary adenoma acoustic neuroma. The most common sites were parasellar region cavernous sinuses. Most (79%) had surgical debulking prior SRT. 10-12 daily. Patient positioning frames highly precise. Acute subacute side minimal radiographic responses have been similar those expected conventional radiotherapy.(ABSTRACT TRUNCATED AT 250 WORDS)