Integrative analysis of clinical and bioinformatics databases to identify anticancer properties of digoxin

摘要: Cardiac glycosides, such as digoxin, inhibit Na+/K+-ATPases and cause secondary activation of Na+/Ca2+ exchangers. Preclinical investigations have suggested that digoxin may anticancer properties. In order to clarify the functional mechanisms in cancer, we performed an integrative analysis clinical bioinformatics databases. The US Food Drug Administration Adverse Event Reporting System Japan Medical Data Center claims database were used databases evaluate reporting odds ratios adjusted sequence ratios, respectively. BaseSpace Correlation Engine Connectivity Map investigate molecular pathways related mechanisms. Clinical analyses inverse association between four cancers: gastric, colon, prostate haematological malignancy. exert effect via peroxisome proliferator-activated receptor α apoptotic caspase cascade pathways. Our revealed possibility a drug repositioning candidate for cancers.