Isolation and comparison of mesenchymal stem cell-like cells derived from human gastric cancer tissues and corresponding ovarian metastases
作者： KUNYAN ZHOU , MAN XIA , BO TANG , DARONG YANG , NIANLI LIU
关键词: Antigen 、 Mesenchymal stem cell 、 Cancer stem cell 、 Biology 、 Cell cycle 、 Oncogene 、 Pathology 、 Carcinogenesis 、 Cell 、 Cancer
摘要: Mesenchymal stem cell (MSC)-like cells have been isolated from various types of tumor. It has previously reported that MSCs are involved in tumorigenesis and its prognosis. The aim the present study was to isolate compare MSC-like human gastric cancer (GC) metastatic deposits ovarian tissue. were (hGC-MSCs) corresponding tissues (hGCOM-MSCs) 40 patients. characteristics hGC-MSCs hGCOM-MSCs, including their morphology, surface antigens, specific gene expression differentiation potential, similar those derived bone marrow (hBM-MSCs) but different GC cells. In conclusion, demonstrated could be tissue tissues. existence suggests they may a potential target for therapy, provides an experimental foundation investigating role initiation progression metastasis GC.
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