The Relationship between Red Blood Cell Distribution Width and Incident Diabetes in Chinese Adults: A Cohort Study.

摘要: Background Previous studies reported the controvertible association between red blood cell distribution width (RDW) and diabetes. The aim of this study is to explore whether RDW associated with incident Methods We performed cohort in 16,971 Chinese adults (9,956 men 7,015 women, aged 43.3 ± 12.8 years). level was measured at baseline (2014). All participants were further classified into four quartile groups based on RDW. Fasting glucose (FBG) glycated hemoglobin A1c (HbA1c) annually during follow-up (2014-2019). Diabetes diagnosed if either FBG ≥ 7.0 mmol/L or HbA1c 6.5%. used Cox proportional hazards regression model evaluate Results identified 2,703 new cases diabetes five-year follow-up. incidence 15.9%. Comparing lowest group (reference group), adjusted hazard ratios (HR) for risk 1.31 (95% CI: 1.16, 1.48) highest (p trend < 0.001), after adjustment potential confounders. Further adjusting did not materially change Each unit increase a 16% higher (HR = 95% 1.06, 1.26) fully model. Sensitivity analysis generated similar results prospective analyses excluding participants, who are overweight obesity, elevated pressure, decreased eGFR, those anemia baseline. Conclusions High high developing adults. As an inexpensive, noninvasive, convenient indicator, might be considered inclusion assessment high-risk