Characterization and in vivo pharmacological rescue of a Wnt2-Gata6 pathway required for cardiac inflow tract development.
作者： Ying Tian , Lijun Yuan , Ashley M. Goss , Tao Wang , Jifu Yang
DOI: 10.1016/J.DEVCEL.2010.01.008
关键词: Posterior pole 、 Cell biology 、 Signal transduction 、 Mesoderm 、 Internal medicine 、 Morphogenesis 、 GATA6 、 Wnt signaling pathway 、 Endocrinology 、 WNT2 、 Phenotype 、 Biology
摘要: Little is understood about the molecular mechanisms underlying morphogenesis of posterior pole heart. Here we show that Wnt2 expressed specifically in developing inflow tract mesoderm, which generates portions atria and atrio-ventricular canal. Loss results defective development heart, resulting a phenotype resembling human congenital heart syndrome complete common The number proliferation second field progenitors reduced Wnt2(-/-) mutants. Moreover, these defects can be rescued temporally restricted manner through pharmacological inhibition Gsk-3beta. We also works feedforward transcriptional loop with Gata6 to regulate cardiac development. These data reveal pathway regulating mesoderm demonstrate cardiovascular caused by loss Wnt signaling pharmacologically vivo.
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