New amino butenolides from the bulbs of Fritillaria unibracteata.
作者： Juan Liu , Cheng Peng , Cheng-Jun He , Jian-Lin Liu , Ya-Cong He
DOI: 10.1016/J.FITOTE.2014.07.009
关键词: In vitro 、 Fritillaria unibracteata 、 Biology 、 Human cancer 、 Liliaceae 、 Two-dimensional nuclear magnetic resonance spectroscopy 、 Stereochemistry
摘要: Five new amino γ-butenolides, fritenolide A (1), B (2), C (3), D (4), and E (5), along with four known compounds, were isolated from the bulbs of Fritillaria unibracteata. Their structures were determined by spectroscopic analysis, including 1D NMR, 2D NMR, HRESIMS, HRESIMS/MS, IR, and CD techniques. All isolates were evaluated for the protective activity on injured hepatocytes and cytotoxic activity on human cancer cells in vitro. The unusual amino butenolides were isolated from the Liliaceae family for the first time.
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researchgate.net 参考文章(26)
Xiao-Hua Wei, Sheng-Jie Yang, Na Liang, De-Yu Hu, Lin-Hong Jin, Wei Xue, Song Yang, Chemical Constituents of Caesalpinia decapetala (Roth) Alston Molecules. ,vol. 18, pp. 1325- 1336 ,(2013) , 10.3390/MOLECULES18011325
Ih-Sheng Chen, I-Lun Lai-Yaun, Chang-Yih Duh, Ian-Lih Tsai, Cytotoxic butanolides from Litsea akoensis Phytochemistry. ,vol. 49, pp. 745- 750 ,(1998) , 10.1016/S0031-9422(98)00129-0
KAZUHIRO YOSHIKAWA, TAKAHIDE TAKADERA, KYOKO ADACHI, MIYUKI NISHIJIMA, HIROSHI SANC, Korormicin, a Novel Antibiotic Specifically Active against Marine Gram-negative Bacteria, Produced by a Marine Bacterium The Journal of Antibiotics. ,vol. 50, pp. 949- 953 ,(1997) , 10.7164/ANTIBIOTICS.50.949
Qing-Yao Shou, Qing Tan, Zheng-Wu Shen, A novel sulfur-containing diterpenoid from Fritillaria anhuiensis Tetrahedron Letters. ,vol. 50, pp. 4185- 4187 ,(2009) , 10.1016/J.TETLET.2009.05.002
Xiao Pei-Gen, Jiang Yan, Li Ping, Luo Yi-Bo, Liu Yong, The botanical origin and pharmacophylogenetic treatment of Chinese materia medica Beimu Journal of Systematics and Evolution. ,vol. 45, pp. 473- 487 ,(2007) , 10.1360/APS06113
Sachiko Tsukamoto, Haruko Kato, Hiroshi Hirota, Nobuhiro Fusetani, PIPECOLATE DERIVATIVES, ANTHOSAMINES A AND B, INDUCERS OF LARVAL METAMORPHOSIS IN ASCIDIANS, FROM A MARINE SPONGE ANTHOSIGMELLA AFF. RAROMICROSCLERA Tetrahedron. ,vol. 51, pp. 6687- 6694 ,(1995) , 10.1016/0040-4020(95)00322-Y
Kazotomo Ori, Yoshihiro Mimaki, Yutaka Sashida, Tamotsu Nikaido, Taichi Ohmoto, Steroidal alkaloids from the bulbs of Fritillaria persica Phytochemistry. ,vol. 31, pp. 4337- 4341 ,(1992) , 10.1016/0031-9422(92)80470-Y
Yasuo Kimura, Takashi Mizuno, Tsuyoshi Kawano, Katsuhide Okada, Atsumi Shimada, Peniamidienone and penidilamine, plant growth regulators produced by the fungus Penicillium sp. No. 13 Phytochemistry. ,vol. 53, pp. 829- 831 ,(2000) , 10.1016/S0031-9422(99)00492-6
X ZHANG, P GEOFFROY, M MIESCH, D JULIENDAVID, F RAUL, D AOUDEWERNER, E MARCHIONI, Gram-scale chromatographic purification of β-sitosterol: Synthesis and characterization of β-sitosterol oxides Steroids. ,vol. 70, pp. 886- 895 ,(2005) , 10.1016/J.STEROIDS.2005.06.003
Shuo Shen, Guoyu Li, Jian Huang, Chaojun Chen, Bu Ren, Ga Lu, Yong Tan, Jiaxu Zhang, Xian Li, Jinhui Wang, Steroidal saponins from Fritillaria pallidiflora Schrenk Fitoterapia. ,vol. 83, pp. 785- 794 ,(2012) , 10.1016/J.FITOTE.2012.03.008