Stem Cells: A Renaissance in Human Biology Research

作者: Jun Wu , Juan Carlos Izpisua Belmonte

DOI: 10.1016/J.CELL.2016.05.043

关键词: Cognitive scienceThe RenaissanceHuman development (biology)Human materialLimited accessBiologyStem cellInduced pluripotent stem cellCytological TechniquesHuman biology

摘要: The understanding of human biology and how it relates to that other species represents an ancient quest. Limited access material, particularly during early development, has restricted researchers only scratching the surface this inherently challenging subject. Recent technological innovations, such as single cell "omics" stem derivation, have now greatly accelerated our ability gain insights into uniquely biology. opportunities afforded delve molecularly scarce material model embryogenesis pathophysiological processes are leading new development changing disease choice therapy options.

参考文章(142)
John W Haycock, None, 3D cell culture: a review of current approaches and techniques. Methods of Molecular Biology. ,vol. 695, pp. 1- 15 ,(2011) , 10.1007/978-1-60761-984-0_1
Ferdinand von Meyenn, Wolf Reik, Forget the Parents: Epigenetic Reprogramming in Human Germ Cells Cell. ,vol. 161, pp. 1248- 1251 ,(2015) , 10.1016/J.CELL.2015.05.039
Stacy R. Finkbeiner, David R. Hill, Christopher H. Altheim, Priya H. Dedhia, Matthew J. Taylor, Yu-Hwai Tsai, Alana M. Chin, Maxime M. Mahe, Carey L. Watson, Jennifer J. Freeman, Roy Nattiv, Matthew Thomson, Ophir D. Klein, Noah F. Shroyer, Michael A. Helmrath, Daniel H. Teitelbaum, Peter J. Dempsey, Jason R. Spence, Transcriptome-wide Analysis Reveals Hallmarks of Human Intestine Development and Maturation In Vitro and In Vivo Stem cell reports. ,vol. 4, pp. 1140- 1155 ,(2015) , 10.1016/J.STEMCR.2015.04.010
M. Azim Surani, Human Germline: A New Research Frontier Stem cell reports. ,vol. 4, pp. 955- 960 ,(2015) , 10.1016/J.STEMCR.2015.04.014
Jessica Mariani, Gianfilippo Coppola, Ping Zhang, Alexej Abyzov, Lauren Provini, Livia Tomasini, Mariangela Amenduni, Anna Szekely, Dean Palejev, Michael Wilson, Mark Gerstein, Elena L. Grigorenko, Katarzyna Chawarska, Kevin A. Pelphrey, James R. Howe, Flora M. Vaccarino, FOXG1-Dependent Dysregulation of GABA/Glutamate Neuron Differentiation in Autism Spectrum Disorders Cell. ,vol. 162, pp. 375- 390 ,(2015) , 10.1016/J.CELL.2015.06.034
Minoru Takasato, Pei X. Er, Han S. Chiu, Barbara Maier, Gregory J. Baillie, Charles Ferguson, Robert G. Parton, Ernst J. Wolvetang, Matthias S. Roost, Susana M. Chuva de Sousa Lopes, Melissa H. Little, Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis Nature. ,vol. 526, pp. 564- 568 ,(2015) , 10.1038/NATURE15695
Jun Wu, Daiji Okamura, Mo Li, Keiichiro Suzuki, Chongyuan Luo, Li Ma, Yupeng He, Zhongwei Li, Chris Benner, Isao Tamura, Marie N. Krause, Joseph R. Nery, Tingting Du, Zhuzhu Zhang, Tomoaki Hishida, Yuta Takahashi, Emi Aizawa, Na Young Kim, Jeronimo Lajara, Pedro Guillen, Josep M. Campistol, Concepcion Rodriguez Esteban, Pablo J. Ross, Alan Saghatelian, Bing Ren, Joseph R. Ecker, Juan Carlos Izpisua Belmonte, An alternative pluripotent state confers interspecies chimaeric competency Nature. ,vol. 521, pp. 316- 321 ,(2015) , 10.1038/NATURE14413
Jun Wu, Juan Carlos Izpisua Belmonte, Dynamic Pluripotent Stem Cell States and Their Applications. Cell Stem Cell. ,vol. 17, pp. 509- 525 ,(2015) , 10.1016/J.STEM.2015.10.009
C. W. van den Berg, S. Okawa, S. M. Chuva de Sousa Lopes, L. van Iperen, R. Passier, S. R. Braam, L. G. Tertoolen, A. del Sol, R. P. Davis, C. L. Mummery, Transcriptome of human foetal heart compared with cardiomyocytes from pluripotent stem cells Development. ,vol. 142, pp. 3231- 3238 ,(2015) , 10.1242/DEV.123810
Taka-aki K. Noguchi, Naoto Ninomiya, Mari Sekine, Shinji Komazaki, Pi-Chao Wang, Makoto Asashima, Akira Kurisaki, Generation of stomach tissue from mouse embryonic stem cells Nature Cell Biology. ,vol. 17, pp. 984- 993 ,(2015) , 10.1038/NCB3200