Basic science review on circadian rhythm biology and circadian sleep disorders.
作者： Kong Leong Toh
DOI:
关键词: Bacterial circadian rhythms 、 Circadian clock 、 Neuroscience 、 Circadian rhythm 、 Internal medicine 、 Basic science 、 Endocrinology 、 Biology 、 Entrainment (chronobiology)
摘要: The sleep-wake cycle displays a characteristic 24-hour periodicity, providing an opportunity to dissect the endogenous circadian clock through study of aberrant behaviour. This article surveys properties clocks, with emphasis on mammals. Information was obtained from searches peer-reviewed literature in PUBMED database. Features that are highlighted include known molecular components their entrainment by external time cues and output pathways used clocks regulate metabolism A review human rhythm sleep disorders follows, including recent discoveries genetic basis. concludes discussion future approaches biology
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