The biosynthesis of hydroxycinnamoyl quinate esters and their role in the storage of cocaine in Erythroxylum coca
作者： José Carlos Pardo Torre , Gregor W. Schmidt , Christian Paetz , Michael Reichelt , Bernd Schneider
DOI: 10.1016/J.PHYTOCHEM.2012.09.009
关键词: Acyltransferase 、 Coca 、 Biochemistry 、 Erythroxylum coca 、 Quinic acid 、 Stereochemistry 、 Biosynthesis 、 Chemistry 、 Tropane 、 Tropane alkaloid 、 Chlorogenic acid
摘要: Complexation of alkaloids is an important strategy plants utilize to facilitate storage in vacuoles and avoid autotoxicity. Previous studies have implicated hydroxycinnamoyl quinate esters the complexation purine Coffea arabica. The goal this study was determine if Erythroxylum coca uses similar agents store abundant tropane alkaloids, such as cocaine cinnamoyl cocaine. Metabolite analysis various E. organs established a close correlation between levels those two quinic acid, chlorogenic acid 4-coumaroyl quinate. BAHD acyltransferase catalyzing final step biosynthesis isolated characterized, its gene expression found correlate with alkaloid accumulation. A physical interaction observed quantified vitro using UV NMR spectroscopic methods yielding values reported for caffeine chlorogenate complex C. These results suggest that other large quantities involves partners.
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