Effect of nutritional status of the donor on the quality of hepatic graft. Value of restoration of glycogenic reserves of the donor

摘要: Initial function of the graft is an essential factor for successful liver transplantation. The aim this study was to evaluate influence nutritional status donor on hepatic quality at reperfusion. Livers (n = 41) were taken from pigs normally fed or fasted 24 h and conditioned 2 hours with a solution containing glucose, fructose glutamine. grafts evaluated using original, blood-free isolated perfusion model, after 8 cold storage, 15 min warm ischemia performed prior harvesting. concentration glycogen ATP, measured in vivo biopsies, decreased animals (P less than 0.05 vs fed) restored by conditioning fasted). At time reperfusion following ischemia, liberation aminotransferases lactate dehydrogenase elevated livers coming levels 0.01 After bile secretion during period reestablished Perfusion liver, preceding harvest, glucose plus neoglucogenic precursors enhances reperfusion.(ABSTRACT TRUNCATED AT 250 WORDS)