Biodiversity as a Source of Potent and Selective Inhibitors of Chikungunya Virus Replication
作者： Pieter Leyssen , Jacqueline Smadja , Philippe Rasoanaivo , Ameenah Gurib-Fakim , Mohamad Fawzi Mahomoodally
DOI: 10.1002/9781118460566.CH11
关键词: Viral replication 、 Biology 、 Virology 、 Indian ocean 、 Chikungunya 、 Virus 、 Biodiversity
摘要: 11.1 The epidemiology of chikungunya virusChikungunya virus (CHIKV) was isolated and identified in themid1950sfromtheserumofafebrilepatientduringadengue-likeepidemicinTanzania,EastAfrica.Thevirusandassociateddiseasewerenamedbytheclinicalsymptomsitcaused:‘chikungunya’means‘stoopedwalk’inMakondelanguage,andreferstoalong-lastingpainfularthralgia.Otherclinicalsymptomsaresimilartothoseofdenguefever,includingsuddenandhighfever,nausea,myalgiaandrash. For this reason, has long been confused withdengue,especiallyduringtheacutephase,althoughitslong-lastingsymptomsaremorecharacteristic,especiallythejointpain(Pialoux
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