A novel highly enantio- and diastereoselective synthesis of vitamin E side-chain
作者： Yohei Matsueda , Shiqing Xu , Ei-ichi Negishi
DOI: 10.1016/J.TETLET.2014.12.081
关键词: Acetylation 、 Vitamin E 、 Proton NMR 、 Enantioselective synthesis 、 Synthon 、 Stereochemistry 、 Chemistry 、 Organic chemistry 、 Iodide 、 Side chain 、 Enantiomer
摘要: Abstract A novel highly enantioselective (>99% ee) and diastereoselective (>98% de) method for the synthesis of chiral C 15 vitamin E side-chain 1 was developed. ZACA–lipase-catalyzed acetylation protocol to provide a key α,ω-dioxyfunctional 5 synthon 6 (⩾99% ee), two subsequent Cu-catalyzed alkyl–alkyl cross-coupling reactions enantiomerically pure iodide 4 were employed as steps. H NMR analysis MαNP ester found be convenient measuring enantiomeric purity .
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