Silencing of Irf7 pathways in breast cancer cells promotes bone metastasis through immune escape
作者： Bradley N Bidwell , Clare Y Slaney , Nimali P Withana , Sam Forster , Yuan Cao
DOI: 10.1038/NM.2830
关键词: IRF7 、 Bone metastasis 、 Metastasis 、 Interferon regulatory factors 、 Biology 、 Immune system 、 T cell 、 Immunosurveillance 、 Immunology 、 Acquired immune system
摘要: … genes suppressed in bone metastases are targets of the interferon regulatory factor Irf7. Restoration of … of Irf7 in bone metastases, we generated 4T1.2 clones overexpressing Irf7 (4T1.2-…
nature.com
uq.edu.au
ulb.ac.be
core.ac.uk
elsevier.com
researchgate.net 参考文章(66)
Thomas Mikeska, Jörg Felsberg, Chelsee A. Hewitt, Alexander Dobrovic, Analysing DNA methylation using bisulphite pyrosequencing. Methods of Molecular Biology. ,vol. 791, pp. 33- 53 ,(2011) , 10.1007/978-1-61779-316-5_4
Maria Lelekakis, Jane M. Moseley, T. John Martin, Daphne Hards, Elizabeth Williams, Patricia Ho, Darren Lowen, Jeannie Javni, Fred R. Miller, John Slavin, Robin L. Anderson, A novel orthotopic model of breast cancer metastasis to bone. Clinical & Experimental Metastasis. ,vol. 17, pp. 163- 170 ,(1999) , 10.1023/A:1006689719505
Stephanie K. Bunt, Pratima Sinha, Virginia K. Clements, Jeff Leips, Suzanne Ostrand-Rosenberg, Inflammation Induces Myeloid-Derived Suppressor Cells that Facilitate Tumor Progression Journal of Immunology. ,vol. 176, pp. 284- 290 ,(2006) , 10.4049/JIMMUNOL.176.1.284
Jeremy B. Swann, Yoshihiro Hayakawa, Nadeen Zerafa, Kathleen C. F. Sheehan, Bernadette Scott, Robert D. Schreiber, Paul Hertzog, Mark J. Smyth, Type I IFN contributes to NK cell homeostasis, activation, and antitumor function. Journal of Immunology. ,vol. 178, pp. 7540- 7549 ,(2007) , 10.4049/JIMMUNOL.178.12.7540
Zhiyuan Hu, Cheng Fan, Daniel S Oh, JS Marron, Xiaping He, Bahjat F Qaqish, Chad Livasy, Lisa A Carey, Evangeline Reynolds, Lynn Dressler, Andrew Nobel, Joel Parker, Matthew G Ewend, Lynda R Sawyer, Junyuan Wu, Yudong Liu, Rita Nanda, Maria Tretiakova, Alejandra Ruiz Orrico, Donna Dreher, Juan P Palazzo, Laurent Perreard, Edward Nelson, Mary Mone, Heidi Hansen, Michael Mullins, John F Quackenbush, Matthew J Ellis, Olufunmilayo I Olopade, Philip S Bernard, Charles M Perou, The molecular portraits of breast tumors are conserved across microarray platforms BMC Genomics. ,vol. 7, pp. 96- 96 ,(2006) , 10.1186/1471-2164-7-96
Chris Coppin, Lyly Le, Timothy J Wilt, Christian Kollmannsberger, Targeted therapy for advanced renal cell carcinoma Cochrane Database of Systematic Reviews. ,(2008) , 10.1002/14651858.CD006017.PUB2
Je-In Youn, Srinivas Nagaraj, Michelle Collazo, Dmitry I. Gabrilovich, Subsets of Myeloid-Derived Suppressor Cells in Tumor-Bearing Mice Journal of Immunology. ,vol. 181, pp. 5791- 5802 ,(2008) , 10.4049/JIMMUNOL.181.8.5791
S. Y. Hwang, P. J. Hertzog, K. A. Holland, S. H. Sumarsono, M. J. Tymms, J. A. Hamilton, G. Whitty, I. Bertoncello, I. Kola, A null mutation in the gene encoding a type I interferon receptor component eliminates antiproliferative and antiviral responses to interferons alpha and beta and alters macrophage responses Proceedings of the National Academy of Sciences of the United States of America. ,vol. 92, pp. 11284- 11288 ,(1995) , 10.1073/PNAS.92.24.11284
Ashley Cimino, Marc Halushka, Peter Illei, Xinyan Wu, Saraswati Sukumar, Pedram Argani, Epithelial cell adhesion molecule (EpCAM) is overexpressed in breast cancer metastases Breast Cancer Research and Treatment. ,vol. 123, pp. 701- 708 ,(2010) , 10.1007/S10549-009-0671-Z
David Savitsky, Tomohiko Tamura, Hideyuki Yanai, Tadatsugu Taniguchi, Regulation of immunity and oncogenesis by the IRF transcription factor family Cancer Immunology, Immunotherapy. ,vol. 59, pp. 489- 510 ,(2010) , 10.1007/S00262-009-0804-6