Phenothiazine-induced sleep apneas in normal infants.

摘要: A relationship between sudden infant death syndrome and the use of phenothiazine-containing medications is suspected. In order to investigate influence phenothiazines upon cardiorespiratory sleep characteristics, four normal infants (mean age 15.8 weeks) had polygraphic recordings made for one night. The were repeated three nights later, after daily administration a usual therapeutic dose standard phenothiazine syrup (promethazine, 1 mg/kg body weight per day). monitored six days first treatment. Findings from each infant. second disclosed an increase in time, reduction number duration awakenings, non-rapid eye movement (NREM) III state, movements. During night, showed central apneas, also several episodes obstructive apneas (median seconds). It concluded that promethazine depresses arousal respiratory mechanisms during sleep. This observation reinforces opinion CNS depressants should be avoided less than year age; could result apnea-prone infants.