Multistep Process of Squamous Differentiation of Tracheobronchial Epithelial Cells: Role of Retinoids

摘要: The objective of our research is to elucidate the molecular mechanisms that regulate proliferation and differentiation tracheobronchial epithelial cells. A clear insight into basic these processes required in order understand involved tumor development other pathological conditions. To study regulation epithelium, an vitro cell culture model was developed using rabbit tracheal Our studies were directed towards answering following questions: (1) What capacity cells? (2) Does occur as a multistep process? (3) factors control by what mechanism? (4) are biochemical markers for various differentiated phenotypes at level they controlled? (5) Is there link between growth differentiation?