Characterisation of the Oxygenation Response to Inspired Oxygen Adjustments in Preterm Infants

摘要: Background: Oxygen saturation (SpO2) targeting in the preterm infant may be improved with a better understanding of SpO2 responses to changes inspired oxygen (FiO2). Objective: We investigated first-order FiO2-SpO2 relationship, aiming quantify parameters governing that influences on these and their variability. Methods: In recordings FiO2 from infants continuous positive airway pressure supplemental oxygen, we identified unique adjustments mapped subsequent responses. For as first-order, delay, time constant gain were determined. Clinical physiological predictors sought regression analysis, intra- inter-subject variability was evaluated. Results: 3,788 h available data 47 at 31 (28-33) post-menstrual weeks [median (interquartile range)], 993 followed by response. All response differed between increments decrements, having shorter longer higher [2.9 (1.7-4.8) vs. 1.3 (0.58-2.6), p 2 instability, diminished increasing severity lung dysfunction. Intra-subject all prominent. Conclusions: First-order show variable gain, influenced direction adjustment disease, well substantial intra-subject parameter These findings should taken into account for infants.