Morphine and ketamine inhibit immune function of gastric cancer patients by increasing percentage of CD4(+)CD25(+)Foxp3(+) regulatory T cells in vitro.

作者: Min Hou , Nai-Bao Zhou , Hao Li , Bao-Sheng Wang , Xiu-Qin Wang

DOI: 10.1016/J.JSS.2016.02.031

关键词: ImmunologyFlow cytometryFOXP3CD4-CD8 RatioMorphinePharmacologyCD8Immune systemMedicinePeripheral blood mononuclear cellIonomycin

摘要: … + /CD8 + T cells was significantly increased in the groups M and K3 compared with the control group (P < 0.05) but was significantly decreased in the group K1 compared with the group …

参考文章(35)
David Atkins, Dana Best, Peter Briss, Martin Eccles, Yngve Falck-Ytter, Signe Flottorp, Gordon Guyatt, Robin Harbour, Margaret Haugh, David Henry, Suzanne Hill, Roman Jaeschke, Gillian Leng, Alessandro Liberati, Jacek Mrukowicz Nicola Magrini, James Mason, Philippa Middleton, Dianne O'Connell, Andrew D Oxman, Bob Phillips, Holger J Schünemann, Tessa Tan-Torres Edejer, Helena Varonen, Gunn Vist, John Williams Jr, Stephanie Zaza, Grading quality of evidence and strength of recommendations. BMJ. ,vol. 328, pp. 1490- 1490 ,(2004) , 10.1136/BMJ.328.7454.1490
Tetsuro Sasada, Motohide Kimura, Yuka Yoshida, Michiyuki Kanai, Arimichi Takabayashi, None, CD4+CD25+ regulatory T cells in patients with gastrointestinal malignancies: possible involvement of regulatory T cells in disease progression. Cancer. ,vol. 98, pp. 1089- 1099 ,(2003) , 10.1002/CNCR.11618
Hiromichi Kawaida, Koji Kono, Akihiro Takahashi, Hidemitsu Sugai, Kosaku Mimura, Naoto Miyagawa, Hideo Omata, Akishi Ooi, Hideki Fujii, Distribution of CD4+CD25high regulatory T-cells in tumor-draining lymph nodes in patients with gastric cancer. Journal of Surgical Research. ,vol. 124, pp. 151- 157 ,(2005) , 10.1016/J.JSS.2004.10.004
Junliang Fu, Dongping Xu, Zhenwen Liu, Ming Shi, Ping Zhao, Baoyun Fu, Zheng Zhang, Huiyin Yang, Hui Zhang, Chunbao Zhou, Jinxia Yao, Lei Jin, Huifen Wang, Yongping Yang, Yang-Xing Fu, Fu-Sheng Wang, Increased regulatory T cells correlate with CD8 T-cell impairment and poor survival in hepatocellular carcinoma patients. Gastroenterology. ,vol. 132, pp. 2328- 2339 ,(2007) , 10.1053/J.GASTRO.2007.03.102
H. Wang, V. Daniel, M. Sadeghi, G. Opelz, Plasticity and Overlap of In Vitro–Induced Regulatory T-Cell Markers in Healthy Humans Transplantation Proceedings. ,vol. 45, pp. 1816- 1821 ,(2013) , 10.1016/J.TRANSPROCEED.2012.10.060
Weon Seon Hong, Young Il Min, Young Sook Son, Seok Il Hong, Peripheral Blood Lymphocyte Subsets in Patients with Stomach Cancer Journal of Korean Medical Science. ,vol. 10, pp. 164- 168 ,(1995) , 10.3346/JKMS.1995.10.3.164
Philip D. Greenberg, Cassian Yee, William Y. Ho, Adoptive therapy with CD8+ T cells: it may get by with a little help from its friends Journal of Clinical Investigation. ,vol. 110, pp. 1415- 1417 ,(2002) , 10.1172/JCI17214