Acid mucopolysaccharides of human aorta

摘要: Summary Acid mucopolysaccharide (MPS) contents in the intima and remaining outer wall of human aortas were studied to observe variations with age. Attempts made dissociate changes occurring aging from those related atherogenesis by careful selection vessels. MPS isolated 76 female without lesions, compared 15 samples Negro females, only ones available essentially free atherosclerotic disease. Aortas this population limits study extending into older age groups. Detailed analyses carried out on lesion-free The total amount increases around third decade, more marked compounds intima. Chondroitin sulfates C B both increased concentration then decreased; chondroitin sulfate A progressively increased, while hyaluronic acid heparitin showed a tendency reach peak levels at an early gradually decreased. Other noted, but not sufficient be clearly characterized. importance observing each specific compound tissue are emphasized these types observations.