Utilizing Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) to Analyze Interstitial Fluid Flow and Transport in Glioblastoma and the Surrounding Parenchyma in Human Patients

摘要: Background: Glioblastoma (GBM) is the deadliest and most common brain tumor in adults, with poor survival response to aggressive therapy. Limited access of drugs cells one reason for such grim clinical outcomes. A driving force therapeutic delivery interstitial fluid flow (IFF), both within surrounding parenchyma. However, convective diffusive transport mechanisms are understudied. In this study, we examined application a novel image analysis method measure diffusion GBM patients. Methods: Here, applied an imaging methodology that had been previously tested validated vitro, silico, preclinical models disease archival patient data from Ivy Atlas Project (GAP) dataset. The required use dynamic contrast-enhanced magnetic resonance (DCE-MRI), which readily available database. results, consisted IFF velocity coefficients, were then compared outcomes as survival. Results: We characterized patterns found strong correlations between rates measured tumors parenchymal space, where hypothesized velocities would be higher. Analyzing overall magnitudes indicated significant correlation age cohort. Additionally, neither size nor resection significantly altered magnitude. Lastly, mapped pathways variability degree directionality hypothesize may lead information concerning treatment, invasive spread, progression future studies. Conclusions: An standard DCE-MRI patients offers more regarding around tumor, shows still detected post-resection, indicates correlate prognosis.