Differences in Cardiopulmonary Exercise Test Results by American Thoracic Society/European Respiratory Society-Global Initiative for Chronic Obstructive Lung Disease Stage Categories and Gender

摘要: Background The American Thoracic Society (ATS)/European Respiratory (ERS)-Global Initiative for Chronic Obstructive Lung Disease (GOLD) has developed a new staging system based on the degree of airflow obstruction. Its validity to predict exercise capacity as an outcome not been extensively studied. We hypothesized that performance measured by cardiopulmonary test (CPET) results should decline significantly with each disease stage, independent gender. Methods examined 453 consecutive incremental CPET and pulmonary function tests performed in patients who had referred single respiratory physiology laboratory tertiary care hospital. They were divided into control group (normal lung function) ATS/ERS-GOLD stages 1 4. anthropometrics, peak work (in watts), oxygen uptake liters per kilogram minute percent predicted), breathing reserve arterial blood gas response. compared these between different genders. Results mean (± SD) age entire was 64 ± 11 years, FEV 66 28%, body mass index (BMI) 27.2 5.82 kg/m 2 . Patients stage 4 younger (p Conclusions can be used indicate differences COPD normalize apparent gender disparities. value differentiating requires further studies outcomes.