Development of a novel rat mutant with spontaneous limbic-like seizures.

摘要: Abstract A new epileptic rat mutant with spontaneous seizures was developed by successive mating and selection from an inherited cataract rat. The procedures for developing the symptomatology, electroencephalographic correlates, neuropathology of are reported. It is possible that this stain will provide a useful animal model human temporal lobe epilepsy. usually begin face head myoclonus, followed rearing, generalized clonic tonic convulsions, all which symptomatologically same as limbic seizures. Electrographic recording during convulsive demonstrated sustained spike discharges emerged at hippocampus then propagated to neocortex. Seizures occurred spontaneously without any artificial stimuli. Furthermore, external stimuli such auditory, flashing light, or vestibular stimulations could not elicit attacks. Almost male animals had mostly 5 months after birth, frequency increased aging. Generalized convulsions in approximately 20% female rats. Microdysgenesis, abnormal neuronal clustering, disarrangement, interruption pyramidal neurons hippocampal formation, found young rats yet This microdysgenesis, though be genetically programmed, very interesting aspect relationship between structural abnormalities epileptogenesis mutant. In addition there sprouting mossy fibers into inner molecular layer dentate gyrus those adult repeated convulsions. An increase glial-fibrillary-acidic-protein-positive astrocytes thickened numerous processes, ie, astrogliosis, also cerebral cortex, amygdala region, these animals. Judging characteristics neuropathology, can expected studying