Microorganisms for the production of 2-hydroxyisobutyric acid
作者： Robin E. Osterhout , Mark J. Burk , Anthony P. Burgard , Priti Pharkya
DOI:
关键词: Microorganism 、 Methacrylic acid 、 Nucleic acid 、 Biology 、 Organism 、 Enzyme 、 Biochemistry
摘要: The invention provides a non-naturally occurring microbial organism having 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic pathway. contains at least one exogenous nucleic encoding an enzyme in additionally method for producing acid. can include culturing expressing pathway sufficient amount and under conditions period of time to produce
google.com.ar 参考文章(987)
W.H. HOLMS, The Central Metabolic Pathways of Escherichia coli: Relationship between Flux and Control at a Branch Point, Efficiency of Conversion to Biomass, and Excretion of Acetate Current Topics in Cellular Regulation. ,vol. 28, pp. 69- 105 ,(1986) , 10.1016/B978-0-12-152828-7.50004-4
Thomas A. Morton, Chih-Fong Chou, Lars G. Ljungdahl, Cloning, Sequencing, and Expressions of Genes Encoding Enzymes of the Autotrophic Acetyl-CoA Pathway in the Acetogen Clostridium thermoaceticum Springer New York. pp. 389- 406 ,(1993) , 10.1007/978-1-4615-7087-5_28
George I. Drummond, Joseph R. Stern, Enzymes of Ketone Body Metabolism Journal of Biological Chemistry. ,vol. 235, pp. 318- 325 ,(1960) , 10.1016/S0021-9258(18)69522-5
Yoshiharu Shimomura, Taro Murakami, Naoya Nakai, Boli Huang, John W. Hawes, Robert A. Harris, 3-hydroxyisobutyryl-CoA hydrolase. Methods in Enzymology. ,vol. 324, pp. 229- 240 ,(2000) , 10.1016/S0076-6879(00)24235-3
M T Skarstedt, E Silverstein, Escherichia coli acetate kinase mechanism studied by net initial rate, equilibrium, and independent isotopic exchange kinetics. Journal of Biological Chemistry. ,vol. 251, pp. 6775- 6783 ,(1976) , 10.1016/S0021-9258(17)33012-0
Zadila Suarez de Mata, Javier Arevalo, Howard J. Saz, Propionyl-CoA condensing enzyme from Ascaris muscle mitochondria Archives of Biochemistry and Biophysics. ,vol. 285, pp. 166- 171 ,(1991) , 10.1016/0003-9861(91)90345-J
Daniel Rudman, Alton Meister, Transamination in Escherichia coli. Journal of Biological Chemistry. ,vol. 200, pp. 591- 604 ,(1953) , 10.1016/S0021-9258(18)71404-X
R Paxton, P W Scislowski, E J Davis, R A Harris, Role of branched-chain 2-oxo acid dehydrogenase and pyruvate dehydrogenase in 2-oxobutyrate metabolism Biochemical Journal. ,vol. 234, pp. 295- 303 ,(1986) , 10.1042/BJ2340295
Zadila Suarez de Mata, Richard Lizardo, Francisca Diaz, Howard J. Saz, Propionyl-CoA condensing enzyme from Ascaris muscle mitochondria Archives of Biochemistry and Biophysics. ,vol. 285, pp. 158- 165 ,(1991) , 10.1016/0003-9861(91)90344-I
R Deana, Substrate specificity of a dicarboxyl-CoA: dicarboxylic acid coenzyme A transferase from rat liver mitochondria. Biochemistry international. ,vol. 26, pp. 767- 773 ,(1992)