Compounds for fluorescence imaging
作者： Norbert Lange , Marino A. Campo
DOI:
关键词: Extraction (chemistry) 、 Fluorophore 、 Hydrophilic polymers 、 Lysine 、 Fluorescence-lifetime imaging microscopy 、 Chemistry 、 Organic chemistry 、 Ion exchange 、 Combinatorial chemistry 、 Imaging agent 、 Polymer
摘要: Methods and compositions involving enzyme-activatable fluorophore polymer imaging agents for photodetection of specific tissues and/or human diseases disorders are provided. In certain embodiments, the agent comprises a hydrophilic backbone (e.g., poly(L)lysine), hydrophobic fluorophore, solubilizing agent. The may comprise quarternary ammonium group 1- methylnicotinic group) to enhance self-quenching fluorophore. Various methods generation purification also provided, including solid phase probe extraction or ion exchange purification.
lens.org 参考文章(8)
Aleksi Soini, Niko Meltola, Method for increasing hydrophilicity of fluorescent label compounds ,(2002)
Ching-Hsuan Tung, Sebastian Bredow, Umar Mahmood, Ralph Weissleder, Preparation of a cathepsin D sensitive near-infrared fluorescence probe for imaging Bioconjugate Chemistry. ,vol. 10, pp. 892- 896 ,(1999) , 10.1021/BC990052H
Doris Gabriel, Marino A. Campo, Robert Gurny, Norbert Lange, Tailoring protease-sensitive photodynamic agents to specific disease-associated enzymes. Bioconjugate Chemistry. ,vol. 18, pp. 1070- 1077 ,(2007) , 10.1021/BC060321L
Martin Funovics, Ralph Weissleder, Ching-Hsuan Tung, Protease sensors for bioimaging Analytical and Bioanalytical Chemistry. ,vol. 377, pp. 956- 963 ,(2003) , 10.1007/S00216-003-2199-0
Ralph Weissleder, Ching-Hsuan Tung, Yongdoo Choi, Intramolecularly quenched fluorochrome conjugates and methods of use ,(2007)
Lee Josephson, Ralph Weissleder, Ching-Hsuan Tung, Umar Mahmood, Alexei Bogdanov, Intramolecularly-quenched near infrared fluorescent probes ,(1999)
Norbert Lange, Marino A. Campo, Compounds for photochemotherapy ,(2006)
Andreas Martinus Maria Miltenburg, Cornelis Marius Timmers, Catherina Joanna Van Staveren, Philippus Johannes Marie Galen Van, Anna Maria Helena Boots, Rnaldus Marcellus Alphonsus Knegtel, Modified peptides and peptidomimetics for use in immunotherapy ,(2000)