Advances in Drug Discovery and Development for Pediatric Tuberculosis

摘要: Pediatric tuberculosis is an underappreciated global epidemic estimated to afflict around half a million children worldwide. This problem has historically been overlooked, due in part their low social status and the difficulty diagnosis of children. Children are more susceptible infection disease progression, including rapid dissemination into extrapulmonary sites. Treatment pediatric infections traditionally built agents used treat adult disease, but pathology, drug pharmacokinetics safety window differs from disease. produces additional concerns for discovery development new agents. review examines: (i) current front second line complex resistant how this knowledge can be identify, prioritize dose that may better tolerated populations; (ii) chemistry suitability drugs clinical pipeline treatment indicating several offer significant improvements multi-drug