The prevalence of clinically significant endoscopic findings in primary care patients with uninvestigated dyspepsia: the Canadian Adult Dyspepsia Empiric Treatment - Prompt Endoscopy (CADET-PE) study.

摘要: Summary Background: Uninvestigated dyspepsia is common in family practice. The prevalence of clinically significant upper gastrointestinal findings (CSFs) adult uninvestigated patients, and their predictability based on history, unknown. Methods: Prompt endoscopy was performed within 10 days referral, 1040 patients presenting with at 49 Canadian practitioner centres. Subsequent management strategies during a 6-month follow-up period were determined by the individual practitioners. Results: CSFs identified 58% (603/1040) patients. Erosive oesophagitis most (43%; N = 451); peptic ulcer uncommon (5.3%; N = 55). Alarm symptoms (2.8%; N = 29). Most had least three symptoms, more than 80% six, approximately half eight or more. Based dominant symptom, 463 (45%) ulcer-like, 393 (38%) reflux-like 184 (18%) dysmotility-like dyspepsia. patients' symptom not predictive endoscopic findings. Oesophagitis those finding all subgroups. gastroduodenal similar Helicobacter pylori (H. pylori) infection (30%; 301/1013) associated findings. Conclusions: Dyspepsia subclassifications, are limited value predicting presence nature CSFs. far diagnosis (43% patients). suggests could be initially treated effectively, without endoscopy, using empirical acid suppressive therapy.