High levels of Alzheimer beta-amyloid precursor protein (APP) in children with severely autistic behavior and aggression.

摘要: Autism is characterized by restricted, repetitive behaviors and impairment in socialization communication. Although no neuropathologic substrate underlying autism has been found, the findings of brain overgrowth via neuroimaging studies increased levels brain-derived neurotrophic factor (BDNF) blood favor an anabolic state. We examined acetylcholinesterase, plasma neuronal proteins, secreted beta-amyloid precursor protein (APP), amyloid-beta 40 42 peptides children with without autism. Children severe aggression expressed at two or more times up to four than mild There was a trend for show higher nonamyloidogenic lower compared controls. This favors alpha-secretase pathway (anabolic), opposite what seen Alzheimer disease. Additionally, complex relationship between age, markers found.