The Regulation of CD1d+ and CD1d− Tumors by NKT Cells
作者： Jianyun Liu , Gourapura J. Renukaradhya , Randy R. Brutkiewicz
DOI: 10.1007/978-1-4614-0613-6_5
关键词: Acquired immune system 、 Antigen 、 Cell 、 Biology 、 MHC class I 、 Signaling lymphocytic activation molecule 、 Cancer research 、 Natural killer T cell 、 Immune system 、 CD1D
摘要: Natural killer T (NKT) cells are that also express NK cell markers. Unlike conventional recognize peptide antigens, NKT lipids. CD1d, a MHC class I-like molecule, presents lipid antigens to cells. Upon activation, secrete both Th1 and Th2 cytokines, linking the innate adaptive immune response. Due heterogeneity of cells, their roles in system mixed controversial. Here, we summarize current knowledge as antitumor effector control CD1d+ CD1d− tumors model systems. Overall, exhibit remarkable broad range activities show great potential for immunotherapy.
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