Pharmacokinetics of buprenorphine following intravenous and buccal administration in cats, and effects on thermal threshold.

摘要: This study reports the pharmacokinetics of buprenorphine, following i.v. and buccal administration, relationship between buprenorphine concentration its effect on thermal threshold. Buprenorphine (20 μg/kg) was administered intravenously or buccally to six cats. Thermal threshold determined, arterial blood sampled prior to, at various times up 24 h drug administration. Plasma determined using liquid chromatography/mass spectrometry. Compartment models were fitted time-concentration data. Pharmacokinetic/pharmacodynamic concentration-thermal significantly higher than baseline 44 min after 7, 24, 104 A two- three-compartment model best data respectively. Following mean ± SD volume distribution steady-state (L/kg), clearance (mL·min/kg), terminal half-life (h) 11.6 8.5, 23.8 3.5, 9.8 3.5. absorption 23.7 9.1 min, 8.9 4.9 h. An effect-compartment with a simple maximum predicted time-course Median (range) ke0 EC50 0.003 (0.002-0.018)/min 0.599 (0.073-1.628) ng/mL (i.v.), 0.017 (0.002-0.023)/min 0.429 (0.144-0.556) (buccal).