Biochemical Modulation of 5-Fluorouracil by Pala: Mechanism of Action
作者： Daniel S. Martin
DOI: 10.1007/978-1-4615-2488-5_17
关键词: Cancer 、 Fluorouracil 、 Biochemical modulation 、 Cancer research 、 In vivo 、 Therapeutic index 、 Cancer cell 、 Medicine 、 Chemotherapy 、 Mechanism of action
摘要: Selectivity is, of course, the key to all chemotherapy. However, selectivity is very difficult achieve against cancer cells in vivo because biochemical differences between and normal are quantitative rather than qualitative. Consequently, anticancer agents have a narrow therapeutic index and, therefore, chemotherapy frequently toxic patient as well tumor.
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