A review of the efficacy of traditional Iranian medicine for inflammatory bowel disease

摘要: The etiology of inflammatory bowel disease (IBD) is not yet known, but many factors such as defects in the immune system, oxidative stress, microbial content gastrointestinal tract, nuclear factor (NF)-κB, nitric oxide (NO), cyclooxygenase-2 (Cox-2), and leukotriene B4 (LB4) are thought to play a role its pathogenesis. In traditional Iranian medicine (TIM), several medicinal plants be effective for treatment IBD. this study, information on all these remedies were derived from available old sources documents or notes books added modern medical databases covering vitro, vivo clinical trials. For some plants, only one two mechanisms action have been found Cassia fistula, Lepidium sativum, Bunium persicum. However, various known. example, Commiphora mukul IBD due immunomodulatory, antioxidant, antibacterial properties it decreases NF-κB, NO Cox-2. Another herb, Plantago ovata, has anti-inflammatory wound healing activities LB4. Considering combination them may useful because their Pistacia lentiscus, persicum, Solanum nigrum, Boswellia, ovata mukul. herbal products used TIM oleogum resin myrrha, seeds Ocimum basilicum, Linum usitatissimum, gum Dracaena cinnabari, major, Lallementia royleana, Allium porrum, there no enough studies confirm benefits It suggested that an evaluation effects different aspects should performed.