Stepwise Recruitment of Transcellular and Paracellular Pathways Underlies Blood-Brain Barrier Breakdown in Stroke

作者: Daniel Knowland , Ahmet Arac , Kohei J. Sekiguchi , Martin Hsu , Sarah E. Lutz

DOI: 10.1016/J.NEURON.2014.03.003

关键词: TranscellularTight junctionCell biologyNeuroscienceBlood–brain barrierParacellular transportCaveolaeGenetically modified mouseBarrier functionBiologyTranscytosis

摘要: … leakage across the BBB in vivo, using two-photon microscopy in the t-MCAO stroke model. … During reperfusion after ischemic stroke, there is a biphasic increase in BBB permeability …

参考文章(58)
William Schubert, Philippe G. Frank, Babak Razani, David S. Park, Chi-Wing Chow, Michael P. Lisanti, Caveolae-deficient Endothelial Cells Show Defects in the Uptake and Transport of Albuminin Vivo Journal of Biological Chemistry. ,vol. 276, pp. 48619- 48622 ,(2001) , 10.1074/JBC.C100613200
Kazumasa Morita, Hiroyuki Sasaki, Mikio Furuse, Shoichiro Tsukita, Endothelial Claudin: Claudin-5/Tmvcf Constitutes Tight Junction Strands in Endothelial Cells Journal of Cell Biology. ,vol. 147, pp. 185- 194 ,(1999) , 10.1083/JCB.147.1.185
Haixia Jiao, Zhenhua Wang, Yunhui Liu, Ping Wang, Yixue Xue, Specific role of tight junction proteins claudin-5, occludin, and ZO-1 of the blood-brain barrier in a focal cerebral ischemic insult. Journal of Molecular Neuroscience. ,vol. 44, pp. 130- 139 ,(2011) , 10.1007/S12031-011-9496-4
Maya Simionescu, Doina Popov, Anca Sima, Endothelial transcytosis in health and disease Cell and Tissue Research. ,vol. 335, pp. 27- 40 ,(2009) , 10.1007/S00441-008-0688-3
Jean-François Jasmin, Samit Malhotra, Manjeet Singh Dhallu, Isabelle Mercier, Daniel M. Rosenbaum, Michael P. Lisanti, Caveolin-1 Deficiency Increases Cerebral Ischemic Injury Circulation Research. ,vol. 100, pp. 721- 729 ,(2007) , 10.1161/01.RES.0000260180.42709.29
Sukriti Nag, Roopa Venugopalan, Duncan J. Stewart, Increased caveolin-1 expression precedes decreased expression of occludin and claudin-5 during blood–brain barrier breakdown Acta Neuropathologica. ,vol. 114, pp. 459- 469 ,(2007) , 10.1007/S00401-007-0274-X
Axel Nimmerjahn, Eran A. Mukamel, Mark J. Schnitzer, Motor behavior activates Bergmann glial networks. Neuron. ,vol. 62, pp. 400- 412 ,(2009) , 10.1016/J.NEURON.2009.03.019
Alan S Go, Dariush Mozaffarian, Véronique L Roger, Emelia J Benjamin, Jarett D Berry, William B Borden, Dawn M Bravata, Shifan Dai, Earl S Ford, Caroline S Fox, Sheila Franco, Heather J Fullerton, Cathleen Gillespie, Susan M Hailpern, John A Heit, Virginia J Howard, Mark D Huffman, Brett M Kissela, Steven J Kittner, Daniel T Lackland, Judith H Lichtman, Lynda D Lisabeth, David Magid, Gregory M Marcus, Ariane Marelli, David B Matchar, Darren K McGuire, Emile R Mohler, Claudia S Moy, Michael E Mussolino, Graham Nichol, Nina P Paynter, Pamela J Schreiner, Paul D Sorlie, Joel Stein, Tanya N Turan, Salim S Virani, Nathan D Wong, Daniel Woo, Melanie B Turner, None, Heart Disease and Stroke Statistics—2013 Update A Report From the American Heart Association Circulation. ,vol. 127, ,(2013) , 10.1161/CIR.0B013E31828124AD
Chris B Schaffer, Beth Friedman, Nozomi Nishimura, Lee F Schroeder, Philbert S Tsai, Ford F Ebner, Patrick D Lyden, David Kleinfeld, Two-photon imaging of cortical surface microvessels reveals a robust redistribution in blood flow after vascular occlusion. PLOS Biology. ,vol. 4, ,(2006) , 10.1371/JOURNAL.PBIO.0040022