Anti-Diabetic Effect of Pectinase-Processed Ginseng Radix (GINST) in High Fat Diet-Fed ICR Mice
作者： Hai Dan Yuan , Hai Yan Quan , Mi-Song Jung , Su-Jung Kim , Bo Huang
DOI: 10.5142/JGR.2011.35.3.308
关键词: Ginseng 、 Type 2 diabetes 、 Insulin 、 Medicine 、 AMPK 、 Endocrinology 、 GLUT4 、 Insulin resistance 、 Glucose transporter 、 AMP-activated protein kinase 、 Internal medicine
摘要: In the present study, we investigate anti-diabetic effect of pectinase-processed ginseng radix (GINST) in high fat diet-fed ICR mice. The mice were divided into three groups: regular diet group, control group (HFD), and GINST-treated group. To induce hyperglycemia, fed a for 10 weeks, administered with 300 mg/ kg GINST once day 5 weeks. Oral glucose tolerance test revealed that improved after challenge. Compared to HFD fasting blood insulin levels decreased by 57.8% (p<0.05) 30.9% (p<0.01) respectively. With plasma levels, resistance index was reduced 68.1% compared Pancreas preserved morphological integrity islets consequently having more contents. addition, up-regulated phosphorylated AMP-activated protein kinase (AMPK) its target molecule, transporter 4 (GLUT4) expression skeletal muscle. Our results suggest ameliorates hyperglycemia through activation AMPK/ GLUT4 signaling pathway, has therapeutic potential type 2 diabetes.
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