Superparamagnetic nanoparticles as vectors for inner ear treatments: driving and toxicity evaluation
作者： Yann Nguyen , Charlotte Celerier , Romain Pszczolinski , Julien Claver , Ulrick Blank
DOI: 10.3109/00016489.2015.1129069
关键词: Confocal microscopy 、 Toxicity 、 Controlled release 、 Inner ear 、 Flow cytometry 、 Biomedical engineering 、 Anatomy 、 Cochlea 、 Drug delivery 、 Chemistry 、 In vivo
摘要: AbstractConclusion Super paramagnetic nanoparticles (MNP) are a promising vector to achieve controlled drug delivery into the cochlea.Objective The goal of study was evaluate toxicological risk MNP upon inner ear.Methods Fe3O4-MNP displacement studied in various catheter materials, shape, and solvent with local magnetic field. EC5V cells (derived from ear) were cultured (100 500 nm) at concentrations or without MNP. Cell survival assessed flow cytometry analysis. Localization within confocal microscopy. In vivo, single intra-cochlear administration 200 nm (3 × 1010MNP/mL, n = 8; 1.5 × 1012 MNP/mL, n = 6) saline (n = 14) performed guinea pigs. Hearing thresholds auditory brainstem responses Day 7.Results could be concentrated different locations sequential activation solenoids. internalized cytoplasm, but not nucle...
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