[Monoaminergic transmitters in the cerebrospinal fluid of patients with acute, chronic, and intermittent pain. Interface between pain and depression?].

摘要: BACKGROUND AND STUDY PURPOSE Pain and depression share similar neurobiological characteristics, it is a common clinical observation that pain may coincide in the same patient. They also appear to influence each other process of chronification. Furthermore, there complex coupling by monoaminergic transmitter system. PATIENTS METHODS On basis these findings, norepinephrine (NE), epinephrine (E), dopamine (DOP), 5-hydroxyindoleacetic acid (5-HIAA), homovanillic (HVA), vanillylmandelic (VMA) concentrations were determined cerebrospinal fluid (CSF) patients with acute (20), chronic (27), episodic syndrome (44) prospective study. The biochemical parameters correlated self-assessment scores. control group consisted 13 pain-free diseases affecting muscular RESULTS Patients syndromes had significantly more depressive psychovegetative symptoms compared pain. In pain, DOP was higher than controls patients. addition positively score (p*<0.05). NE 5-HIAA duration disease lower group. neither two groups could significant correlations be established between or all groups, positive seen neurotransmitter their metabolites. CONCLUSION pathological decrease CSF points crucial role noradrenergic serotonergic systems generation, modulation, perpetuation syndromes. It indicates antidepressants are effective drugs diseases. However, discriminative neurochemical pattern not established. demonstration polyvalent different neurotransmitters indicative cortical, limbic, hypothalamic neuronal networks on one hand nociceptive descending system genesis depression.