Twenty-four-hour energy expenditure in Pima Indians with Type 2 (non-insulin-dependent) diabetes mellitus

摘要: To assess the impact of Type 2 (non-insulin-dependent) diabetes mellitus on energy metabolism, 24-h expenditure, basal metabolic rate and sleeping were measured in a respiratory chamber 151 Pima Indians, 102 with normal glucose tolerance (67 male/35 female, (mean ± SD) 28±7 years, 99±24 kg, 32±9% body fat) 49 (22 male/27 35±11 107±33 39±7% fat), after at least 3 days weight maintaining diet. After adjustment for differences fat-free mass, fat age sex, significantly higher diabetic patients than control subjects (72 kcal/day, p<0.05; 99 p<0.005; p<0.001 respectively). Spontaneous physical activity was similar both groups whereas thermic effect food, calculated as mean expenditure corrected throughout day above expressed percentage intake, lower (17.1±7.1 vs 19.8±5.6%, p<0.05). Adjusted values correlated hepatic endogenous production (r=0.22, r=0.22, r=0.31, p<0.01 Therefore, increased rates, resulting sedentary may play role loss so often observed addition to from glycosuria.