Probing the pathobiology of response to all-trans retinoic acid in acute promyelocytic leukemia: premature chromosome condensation/fluorescence in situ hybridization analysis.
作者： RC Vyas , SR Frankel , P Agbor , WH Jr Miller , RP Jr Warrell
DOI: 10.1182/BLOOD.V87.1.218.218
关键词: Acute promyelocytic leukemia 、 Premature chromosome condensation 、 Fluorescence in situ hybridization 、 Molecular biology 、 Haematopoiesis 、 Cytogenetics 、 Chromosomal translocation 、 Retinoic acid 、 Pathology 、 Biology 、 Bone marrow
摘要: The response of acute promyelocytic leukemia (APL) peripheral blood and bone marrow cells to trans-retinoic acid (RA) was cytogenetically characterized during RA treatment using the techniques premature chromosome condensation (PCC) fluorescence in situ hybridization (FISH). Before treatment, predominant immature were found have t(15;17), whereas residual mature granulocytes diploid lacked evidence translocation. In an increase leukocyte count noted. majority these exhibited a t(15;17). Subsequently (eg, between days 6 23), 32% 91% maturing myeloid still appearance t(15;17) gradually elements suggests that contributed release maturation block leukemic elements. As responding patients obtained complete remission, without translocation prevailed marrow. 16 studied after 1 month all but 2 showed cells. disappeared 18 later patient, second patient clinical relapse 20 later. These results suggest with APL is associated maturation, subsequent loss elements, preferential regeneration normal hematopoietic
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