Antiobesity effect of ginsenoside Rg3 involves the AMPK and PPAR‐γ signal pathways

作者: Jin-Taek Hwang , Myoung-Su Lee , Hyun-Jin Kim , Mi-Jeong Sung , Hye Young Kim

DOI: 10.1002/PTR.2606

关键词: EndocrinologyProtein kinase AGinsengPeroxisome proliferator-activated receptorAdipocyteContext (language use)AMPKInternal medicineAMP-activated protein kinaseBiologyGinsenosidePharmacology

摘要: … antidiabetic and anticancer effects. This study investigated the molecular basis of ginsenoside Rg3, a red … The data show that ginsenoside Rg3 was effective in the inhibition of adipocyte …

参考文章(26)
Karen J. Auborn, Saijun Fan, Eliot M. Rosen, Leslie Goodwin, Alamelu Chandraskaren, David E. Williams, DaZhi Chen, Timothy H. Carter, Indole-3-Carbinol Is a Negative Regulator of Estrogen Journal of Nutrition. ,vol. 133, ,(2003) , 10.1093/JN/133.7.2470S
F. Zhang, B. Lavan, F.M. Gregoire, Peroxisome proliferator-activated receptors as attractive antiobesity targets. Drug News & Perspectives. ,vol. 17, pp. 661- ,(2004) , 10.1358/DNP.2004.17.10.873918
Mhairi C. Towler, D. Grahame Hardie, AMP-Activated Protein Kinase in Metabolic Control and Insulin Signaling Circulation Research. ,vol. 100, pp. 328- 341 ,(2007) , 10.1161/01.RES.0000256090.42690.05
Chin-Lin Hsu, Gow-Chin Yen, Effects of capsaicin on induction of apoptosis and inhibition of adipogenesis in 3T3-L1 cells. Journal of Agricultural and Food Chemistry. ,vol. 55, pp. 1730- 1736 ,(2007) , 10.1021/JF062912B
Michael Lehrke, Mitchell A. Lazar, The Many Faces of PPARγ Cell. ,vol. 123, pp. 993- 999 ,(2005) , 10.1016/J.CELL.2005.11.026
Jin-Taek Hwang, Soon-Hee Kim, Myoung-Su Lee, Sung Hee Kim, Hye-Jeong Yang, Min-Jung Kim, Hak-Soo Kim, Joohun Ha, Myung Sunny Kim, Dae Young Kwon, Anti-obesity effects of ginsenoside Rh2 are associated with the activation of AMPK signaling pathway in 3T3-L1 adipocyte Biochemical and Biophysical Research Communications. ,vol. 364, pp. 1002- 1008 ,(2007) , 10.1016/J.BBRC.2007.10.125