Glucagon and Amino Acid Metabolism

摘要: Glucagon is thought to play two major metabolic roles (UNGER and ORCI 1981). One, as shown over 30 years ago by Sutherland associates (Sutherland 1950; et al. 1968), increase blood glucose levels initiating hepatic glycogenolysis. The other promote gluconeogenesis, thus serving maintain production, even in the face of increased insulin levels, such after a high protein meal when glucagon are both increased. Therefore, has very significant role, especially carbohydrate deficiency, be it fed or fasted state. also been found decrease amino acid its infusion humans (Fig. 1) experimental animals (Helmer 1957; Weinges 1959; Landau Lugibihl 1960; Bromer Chance 1969; Marliss 1970; Aoki 1974). This effect apparent subjects with glucagon-producing tumors, who have strikingly low concentrations all almost acids (Mallinson 1974; Holst 1978, 1979; Kessinger 1977; Boden 1978; Riddle Stacpoole 1981; Bhathena response could result from trapping and, possibly, global regulating gradients across cells, synthesis breakdown.