Posterior fossa syndrome in adults: A new case and comprehensive survey of the literature

摘要: Although the posterior fossa syndrome (PFS) can be considered as an aetiologically heterogeneous condition affecting children and adults, it most often occurs in paediatric patients after cerebellar tumour surgery. In with a tumoural aetiology, is typically characterised by short symptom-free postoperative period followed mutism of variable duration behavioural affective changes. More than 200 cases have been described but reports adult are extremely rare. This paper discusses PFS adults on basis comprehensive literature survey describes pre- findings new patient. preoperative phase, cognitive, abnormalities were identified, matching diagnosis cognitive (CCAS) (Schmahmann Sherman, 1998; Schmahmann, 2004). The immediate course was prefrontal-like abnormalities, peduncular hallucinations confusion evolving to psychosis. Akinetic subsequently developed, lasted for 12 days then alternated episodes diminished responsiveness which pathological laughing crying (PLC) occurred. resolved treatment non-ergoline dopamine-agonist CCAS persisted during longitudinal follow-up. From semiological point view "relapsing-remitting akinetic mutism" PLC our patient might add relevant information current insights clinical expression PFS. As evidenced close parallelism between single photon emission computed tomography (SPECT) findings, well seem reflect functional disruption cerebello-cerebral network involved functions. These may indicate that both syndromes share overt resemblances common pathophysiological substrate. Consequently, regarded cerebellar-induced conditions showing different aspects spectrum range degree severity symptom duration.